Conditions Treated by CBD

Conditions Treated by CBD 2018-11-02T12:25:21-04:00

Conditions

Scientific research has shown CBD may be therapeutic for many conditions. In compiling a list of conditions that CBD may help, we examined hundreds of peer-reviewed articles in scientific journals. Relevant reports have been culled primarily from PubMed, online service of the U.S. National Library of Medicine. To these highly technical reports, we have added articles from O’Shaughnessy’s and a few stories from general interest publications.

Most of the PubMed material consists of abstracts on preclinical research involving single cannabinoid molecules, test tubes, petri dishes, animal experiments, and in some cases human cell-line studies. Although all mammals have cell receptors that respond pharmacologically to cannabinoid compounds, data from animal experiments and other preclinical research is not always applicable to humans. GW Pharmaceuticals has conducted successful trials of Sativex, a whole plant CBD-rich Cannabidiol extract, mainly for people suffering from neuropathic pain; summaries of this research are also included. There have been additional studies with synthetic CBD and whole plant Cannabidiol in Brazil and Israel. Unfortunately, political constraints have blocked clinical-oriented CBD research in the United States.

Most of the reports that follow pertain to cannabidiol. Occasionally articles examine the therapeutic potential of other plant cannabinoids—THC, CBDA (cannabidiol in its raw acid form), THCV, CBG, and CBDV, for example. We’ve also included a few studies that illuminate various aspects of the endocannabinoid system without focusing on CBD.

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Frequently asked questions

Dosage Guidelines 2018-11-02T12:05:57-04:00

Decide how you want to take Cannabidiol. Cannabidiol oil is available in sprays, capsules, edibles and other products.

Find your ratio. Cannabidiol products have varying amounts of CBD and THC. A high CBD or high THC product is not necessarily superior to a strain with a balanced ratio. Find the proper combination to optimize your therapeutic use of Cannabidiol.

Begin with a low dose especially if you have little or no experience with Cannabidiol.

Take a few small doses over the course of the day rather than one big dose.

Use the same dose and ratio for several days. Observe the effects and if necessary adjust the ratio or amount.

Don’t overdo it. “Less is more” is often the case with Cannabidiol therapeutics.

Be aware of possible side effects. Cannabidiol is a safe and forgiving medicine.
Depending upon delivery method and individual tolerance, it can amplify anxiety and mood disorders. Other possible side effects are dry mouth, dizziness and faintness.

Consult your health counselor. Proceed cautiously, especially if you have a history of alcohol or drug abuse, mental illness, or are pregnant or breastfeeding.

Find Your Ratio! 2018-11-02T12:07:41-04:00

Although banned by federal law, dosed Cannabidiol medicine is currently available in the form of concentrated oil extracts, infused sublingual sprays, capsules, edibles, and other products. Potent Cannabidiol oil extracts have varying ratios of CBD and THC that are calibrated to suit the needs and sensitivities of each patient.

For anxiety, depression, spasms, and pediatric seizure disorders, many patients initially find they do best with a moderate dose of a CBD-dominant remedy (a CBD:THC ratio of more than 10:1). But a low THC remedy, while not intoxicating, is not necessarily the best therapeutic option. A combination of CBD and THC will likely have a greater therapeutic effect for a wider range of conditions than CBD or THC alone. For cancer, neurological disease, and many other ailments, patients may benefit from a balanced ratio of CBD and THC.  Extensive clinical research has shown that a 1:1 CBD:THC ratio is effective for neuropathic pain. Optimizing one’s therapeutic use of Cannabidiol may entail a careful, step-by-step process, whereby a patient starts with small doses of a non-intoxicating CBD-rich remedy, observes the results, and gradually increases the amount of THC.

In essence, the goal is to self-administer consistent, measurable doses of a CBD-rich remedy that includes as much THC as a person is comfortable with.

​The Biphasic Effect

Cannabidiol compounds have biphasic properties, which means that low and high doses of the same substance can produce opposite effects. Small doses of Cannabidiol tend to stimulate; large doses sedate. Too much THC, while not lethal, can amplify anxiety and mood disorders. CBD has no known adverse side effects at any dose, but drug interactions can be problematic. An excessive amount of CBD could be less effective therapeutically than a moderate dose. “Less is more” is often the case with respect to Cannabidiol therapy.

“Dosage is everything”—Paracelsus

Cannabidiol Dosing 2018-11-02T12:08:09-04:00

Cannabidiol therapeutics is personalized medicine. The right treatment regimen depends on the person and condition being treated. For maximum therapeutic benefit, choose Cannabidiol products that include both cannabidiol (CBD), a non-intoxicating compound, and tetrahydrocannabinol (THC), the psychoactive component of Cannabidiol. CBD and THC interact to enhance each other’s therapeutic effects. They work best together. A patient’s sensitivity to THC is a key factor to determining the ratio and dosage of CBD-rich medicine. Many people enjoy the Cannabidiol high and can consume reasonable doses of any Cannabidiol product without feeling too high or dysphoric. Others find THC unpleasant. CBD can lessen or neutralize the intoxicating effects of THC. So a greater ratio of CBD-to-THC means less of a “high.”

What is CBD 2018-11-02T12:08:29-04:00

CBD is one of over 60 compounds found in Cannabidiol that belong to a class of ingredients called cannabinoids. Until recently, THC (tetrahydrocannabinol) was getting most of the attention because it’s the ingredient in Cannabidiol that produces mind-altering effects in users, but CBD is also present in high concentrations — and the medical world is realizing that its list of medical benefits continues to grow.

CBD is the major nonpsychoactive component of Cannabidiol sativa. According to a 2013 study published in the British Journal of Clinical Pharmacology, CBD benefits including acting in some experimental models as an anti-inflammatory, anticonvulsant, antioxidant, antiemetic, anxiolytic and antipsychotic agent, and is therefore a potential medicine for the treatment of neuroinflammation, epilepsy, oxidative injury, vomiting and nausea, anxiety and schizophrenia.

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